Leading the clinical development of
fibrinolysis without bleeding
to change the treatment paradigm for
ischemic stroke and heart attack.
Thrombolytic Science (TSI) is a private, clinical stage, vascular medicine & biotech company.
Our Focus
Current treatment options for patients experiencing a stroke or heart attack are limited and delay the
re-establishment of blood flow.
TSI is dedicated to transforming standards of care, by bringing a simple intravenous biotherapy to the patient, closer to the time of onset.
TSI’s bio-inspired solution is
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A low dose, efficacious, safer dual thrombolytic Rx
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Based on a clinically validated mechanism
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To be given on suspicion of a stroke or heart attack
Clinical Trials
TSI recently completed a Phase 1 clinical study confirming the safety and tolerability of its novel tPA / HisproUK dual regimen.
TSI's dual regimen is currently being tested in two Phase 2 clinical trials, one in ischemic stroke patients, and an another in patients with acute myocardial infarction.
Science
tPA's biological role is limited to degrading the surface of the clot.
With TSI’s regimen, once this occurs, the small amount of tPA used is rapidly cleared from the blood flow. HisproUK, TSI's compound, exclusively targets the now degraded clot and dissolves it.
Should there be no degraded clot, as in the case of stroke mimics or a hemorrhagic stroke, HisproUK will remain safely in its inactive pro enzymatic form before being cleared in minutes from the blood flow.
TSI's thrombolytic regimen could therefore be given safely on simple suspicion of an ischemic stroke, as soon as possible after stroke onset.
Team
Management & Directors
Board member
Board member
Advisory Board
Chairman of the Court,
London School of Hygiene
& Tropical Medicine
Non-Executive Chairman,
Cocoon Biotech
Professor of Medicine, Hematology
Adjunct Professor, Neurology,
Washington University
Senior Lecturer,
Harvard Medical School, Former Chief Medical Officer, Chairman & Founder, InfraReDx
1985 Nobel Peace Prize
President & CEO,
Baim Institute
for Clinical Research
Professor of Medicine,
Harvard Medical School
Chairman & Founder, PERFUSE
