Revolutionizing the treatment of 
ischemic stroke and heart attack,

re-establishing blood flow faster,

without bleeding, soon in the ambulance 

Thrombolytic Science (TSci) is a private, clinical stage, vascular medicine & biotech company

Our Focus

Current treatment options for patients experiencing a stroke or heart attack are limited and delay the
re-establishment of blood flow.

TSci is dedicated to transforming standards of care, by bringing a simple intravenous biotherapy to the patient, closer to the time of onset.

 

TSci's bio-inspired solution is 

  • A low dose, efficacious, safer dual thrombolytic Rx

  • Based on a clinically validated mechanism

  • To be given on suspicion of a stroke or heart attack

 

Clinical Trials

TSci recently completed a Phase 1 clinical study confirming the safety and tolerability of its novel tPA / HisproUK dual regimen.  

 

TSci's dual regimen is currently being tested in a Phase 2 clinical trial in ischemic stroke patients.

 
 

Science

tPA's biological role is limited to degrading the surface of the clot.


With TSci’s regimen, once this occurs, the small amount of tPA used is rapidly cleared from the blood flow. HisproUK, TSci's compound, exclusively targets the now degraded clot and dissolves it.

 

Should there be no degraded clot, as in the case of stroke mimics or a hemorrhagic stroke, HisproUK will remain safely in its inactive pro enzymatic form before being cleared in minutes from the blood flow. 

 

TSci's thrombolytic regimen could therefore be given safely on simple suspicion of an ischemic stroke, as soon as possible after stroke onset.

 

Team

Management & Directors

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Alexis Wallace, MScEng, MBA
Chief Executive Officer,

Co-founder & Board member

Victor Gurewich, MD

Chief Scientific Officer,
Co-founder &
Board member

Michael Woehler, PhD

Non-Executive Chairman

of the Board

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Advisory Board

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Annalisa Jenkins, MBBS, FRCP

Chairman of the Court,

London School of Hygiene
Tropical Medicine

Non-Executive Chairman,

Cocoon Biotech

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Gregory J. del Zoppo, M.D.

Professor of Medicine, Hematology

Adjunct Professor, Neurology, 

Washington University

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James E. Muller, M.D.

Senior Lecturer,

Harvard Medical School, Former Chief Medical Officer, Chairman & Founder, InfraReDx

1985 Nobel Peace Prize

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C. Michael Gibson, M.D.

President & CEO,

Baim Institute
for Clinical Research

Professor of Medicine,

Harvard Medical School

Chairman & Founder, PERFUSE

News

October 29, 2021

Thrombolytic Science Awarded US Patent on its Novel Clot-dissolving Therapy

 

February 10, 2021

Thrombolytic Science Reinforces Its IP Portfolio with Patents in Europe, the Commonwealth of Independent States and Japan.  New Patents to Support Global Partnering of Novel Bio-inspired Clot-dissolving Therapy

January 20, 2021

The DSMB of the DUMAS trial reviewed a fifth interim analysis and identified no safety concerns in the first 60 ischemic stroke cases, recommending that the study continue as planned

October 26, 2020

The DMSB of the DUMAS trial, chaired by Professor Michael Hill / U. of Calgary, reviewed a fourth interim analysis and identified no safety concerns in the first 50 ischemic stroke cases, recommending that the study continue as planned

October 30, 2019

Clinical milestone; first patients enrolled in Thrombolytic Science's Phase II ischemic stroke trial at Erasmus Medical School, Rotterdam, NL

May 17, 2019

Thrombolytic Science's Phase II trial in ischemic stroke approved by Erasmus Medical School's IRB

September 5, 2018

NeurologyLive:  Phase II Trial of HisproUK, Low-Dose tPA Dual Therapy for Ischemic Stroke Initiated

May 30, 2018

Thrombolytic Science to Participate in 2018 BIO International Conference

November 15, 2017

Thrombolytic Science appoints Michael Woehler, PhD, Chairman of the board

September 18, 2017

Thrombolytic Science's first-in-man, randomized, double-blind, placebo-controlled Phase I clinical trial demonstrates safety and tolerability of TS01, a sequence of low doses of tPA and HisproUK

 

Publications

 

VIEW>  Gurewich V. Therapeutic Fibrinolysis: How Efficacy and Safety Can Be Improved. JACC 2016.

VIEW>  Bogarty P, Brophy J. STEMI Treatment 2016: Is Outcome Improvement Stalling and If So, Why? DOI 2016.

VIEW>  Pannell R, Li S, Gurewich V. Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA                     plus low-dose mutant proUK. PLoS One. 2015; 10(3):e0122018.

VIEW>  Tomasi S, Sarmientos P, Giorda G, Gurewich V, Vercelli A. Mutant prourokinase with adjunctive C1-inhibitor is an                     effective and safer alternative to tPA in rat stroke. PLoS One. 2011; 6(7):e21999

 
 

Contact

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Thrombolytic Science, LLC
One Broadway,  14 FL
Cambridge, MA 02142