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  • Pannell R, Li S, Gurewich V. Highly effective fibrinolysis by a sequential synergistic combination of mini-dose tPA plus low-dose mutant proUK. PLoS One. 2015; 10(3):e0122018



  • Tomasi S, Sarmientos P, Giorda G, Gurewich V, Vercelli A. Mutant prourokinase with adjunctive C1-inhibitor is an effective and safer alternative to tPA in rat stroke. PLoS One. 2011; 6(7):e21999



  • Gurewich V, Pannell R, Simmons-Byrd A, Sarmientos P, Liu JN, Badylak SF Thrombolysis versus bleeding from hemostatic sites by a prourokinase mutant compared with tissue plasminogen activator.  J Thrombos Haemostas. 2006; 4:1559-1565.


  • Pannell R, Kung W, Gurewich V. C1-inhibitor prevents non-specific plasminogen activation by a prourokinase mutant without impeding fibrin-specific fibrinolysis. J Thrombos Haemostas. 2007; 5:1047-1054.


  • Liu JN, Liu JX, Liu BF, et al. A prourokinase mutant which induces highly effective clot lysis without interfering with hemostasis. Circ Res. 2002; 90:757-763.

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